Mice brains are too different from humans’ to model neurodevelopmental disorders
Most knowledge about how the development of the cerebellum – the brain area that receives and coordinates sensory information and our physical responses to it – comes…
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Human liver-on-a-chip predicts human toxicity better than animal studies
A new organ-on-a-chip system can predict human toxicity that was undetected in animal studies for drugs halted in clinical trials and emphasizes species-specific responses in liver toxicity.
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Time to move beyond the 3R principles
This recently published study says the time has now come to prioritise the Replacement of animals used for scientific purposes, over refinement and reduction strategies. The 21st Century has…
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Book review: Rigor mortis
Scientific research should not be attached to particular dogmas or paradigms but, on the contrary, change its methods according to the results obtained. In his book “Rigor Mortis”, the…
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A 3D Model of the Human Blood Brain Barrier
Researchers at Vanderbilt University have developed a functional 3D in vitro blood-brain barrier model constructed from induced pluripotent stem cell (iPSC)-derived human brain microvascular endothelial cells…
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Pancreas-on-a-Chip Offers New Possibilities for Cystic Fibrosis Research
Researchers at Cincinnati Children’s Hospital Medical Center have developed a human pancreas-on-a-chip to increase our fundamental understanding of the pancreatic function and to identify possible…
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