• The convalescent sera option for containing COVID-19

    With a vaccine for COVID-19 still a long way from being realized, Johns Hopkins University is working to revive a century-old blood-derived treatment in hopes of slowing the spread of the disease.   HUMAN HEALTH ISSUE Even at their most effective – and draconian – containment strategies have only slowed the spread of the respiratory […]

    Continue reading
  • Smoking robot and lung-on-a-chip to study cigarette smoke-induced lung diseases

    Researchers at the Wyss Institute at Harvard University have developed an animal-free science innovation platform by combining a robotic smoking machine with a lung-on-a-chip technology to fully and realistically mimic human smoking patterns. HUMAN HEALTH ISSUE Evaluating the health impact of airborne compounds is critical to determining pathogenesis and mechanisms of injury. Cigarette smoking is […]

    Continue reading
  • Scientists can bio-print a 3D mini liver in 90 days

    Using human blood cells, researchers have succeeded in obtaining hepatic organoids (“mini-livers”) that perform all of the liver’s typical functions, such as producing vital proteins, storing vitamins, and secreting bile, among many others. The innovation permits the production of hepatic tissue in the laboratory in only 90 days and may in the future become an […]

    Continue reading
  • Report on ‘Animal Experimentation: working towards a Paradigm Change’ Book Launch at the European Parliament

    On December 4, 2019 Animal Free Science, together with the Center for Alternatives to Animal Testing (CAAT) organized the launch of the book project entitled ‘Animal Experimentation: Working Towards a Paradigm Change‘ (Brill open access) at the European Parliament, to engage with scientists and politicians and stimulate the transition to better science and healthcare by […]

    Continue reading
  • We don’t want to make mice better but people

    The transition away from animal testing is for the time being a predominantly silent revolution, but alternatives based on human tissues and mini-organs offer the prospect of acceleration. “This is not only much more relevant for patients,” says Christine Mummery from the Leiden University Medical Center (LUMC), “But it is also faster and cheaper in […]

    Continue reading
  • New online database to improve environmental risk assessment of chemicals and avoid animal testing

    The EnviroTox database is an international project, led by the Health and Environmental Sciences Institute and involving the JRC. This public database of ecotoxicological data brings together more than 91,000 curated records for more than 4000 chemicals across 1500 species. The case study published by Connors et al. demonstrated that eco-TTC values can facilitate a […]

    Continue reading
  • Human iPSC-derived heart-on-a-chip technology for early drug discovery and development

    A human iPSC-derived heart-on-a-chip technology can directly measure in vivo cardiac performance and it can be used to assess the effects of novel compounds on contractility early in the drug discovery and development process. HUMAN HEALTH ISSUE Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide (Benjamin et al., 2018). Patients with […]

    Continue reading
  • EU citizens and industry expect ‘big reduction’ in mandatory animal testing

    The European Chemicals Agency (ECHA) and the Joint Research Centre scientists have a key role to play in meeting the demand of EU citizens and industry, who want to see a big reduction in mandatory animal testing via new methodologies, Dr Julia Fentem told EURACTIV in an interview. EURACTIV SPECIAL REPORT ON ALTERNATIVES TO ANIMAL […]

    Continue reading
  • Green MEP Tilly Metz calls for EU action plan on alternatives to animal testing

    All initiatives to promote alternatives to animal testing are welcome, but lawmakers should be bolder and impose some mandatory measures as well, Luxembourgish MEP Tilly Metz has said. EURACTIV SPECIAL REPORT According to the Green MEP, policymakers must not give up their ambition of making  the “3 Rs” approach to animal testing mandatory. The “3 […]

    Continue reading
  • The potential of organoids and kidney-on-a-chip platforms as better predictive models for drug-induced nephrotoxicity

    A new review from scientists at the University of Utrecht considers how the complex nature of the kidney complicates in vitro modeling & suggests where 3D culture & organoid advances can be used to develop better predictive models that could reduce drug-induced nephrotoxicity. HUMAN HEALTH ISSUE The kidneys play an essential role in preserving homeostasis […]

    Continue reading