• Animal-free science innovations for better COVID-19 research

    A great deal of knowledge about the SARS-CoV-2 virus and the COVID-19 disease is needed quickly. In April this year, the Dutch Ministry of Health, Welfare and Sport (VWS) made 40 million euros available to ZonMw and NWO for COVID-19. Experimental animal-free innovations enable research to be carried out better and faster because the results […]

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  • Vaccine testing without animal testing?

    Dutch, Bilthoven based, Intravacc, a global leader in translational research and development of viral and bacterial vaccines, today announced the publication of a study in Scientific Reports on alternatives to the use of laboratory animals in vaccine quality control. The study was conducted together with Leiden Academic Center for Drug Research (LACDR) at Leiden University. […]

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  • The convalescent sera option for containing COVID-19

    With a vaccine for COVID-19 still a long way from being realized, Johns Hopkins University is working to revive a century-old blood-derived treatment in hopes of slowing the spread of the disease.   HUMAN HEALTH ISSUE Even at their most effective – and draconian – containment strategies have only slowed the spread of the respiratory […]

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  • Smoking robot and lung-on-a-chip to study cigarette smoke-induced lung diseases

    Researchers at the Wyss Institute at Harvard University have developed an animal-free science innovation platform by combining a robotic smoking machine with a lung-on-a-chip technology to fully and realistically mimic human smoking patterns. HUMAN HEALTH ISSUE Evaluating the health impact of airborne compounds is critical to determining pathogenesis and mechanisms of injury. Cigarette smoking is […]

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  • Scientists can bio-print a 3D mini liver in 90 days

    Using human blood cells, researchers have succeeded in obtaining hepatic organoids (“mini-livers”) that perform all of the liver’s typical functions, such as producing vital proteins, storing vitamins, and secreting bile, among many others. The innovation permits the production of hepatic tissue in the laboratory in only 90 days and may in the future become an […]

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  • Report on ‘Animal Experimentation: working towards a Paradigm Change’ Book Launch at the European Parliament

    On December 4, 2019 Animal Free Science, together with the Center for Alternatives to Animal Testing (CAAT) organized the launch of the book project entitled ‘Animal Experimentation: Working Towards a Paradigm Change‘ (Brill open access) at the European Parliament, to engage with scientists and politicians and stimulate the transition to better science and healthcare by […]

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  • We don’t want to make mice better but people

    The transition away from animal testing is for the time being a predominantly silent revolution, but alternatives based on human tissues and mini-organs offer the prospect of acceleration. “This is not only much more relevant for patients,” says Christine Mummery from the Leiden University Medical Center (LUMC), “But it is also faster and cheaper in […]

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  • New online database to improve environmental risk assessment of chemicals and avoid animal testing

    The EnviroTox database is an international project, led by the Health and Environmental Sciences Institute and involving the JRC. This public database of ecotoxicological data brings together more than 91,000 curated records for more than 4000 chemicals across 1500 species. The case study published by Connors et al. demonstrated that eco-TTC values can facilitate a […]

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  • Human iPSC-derived heart-on-a-chip technology for early drug discovery and development

    A human iPSC-derived heart-on-a-chip technology can directly measure in vivo cardiac performance and it can be used to assess the effects of novel compounds on contractility early in the drug discovery and development process. HUMAN HEALTH ISSUE Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide (Benjamin et al., 2018). Patients with […]

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  • EU citizens and industry expect ‘big reduction’ in mandatory animal testing

    The European Chemicals Agency (ECHA) and the Joint Research Centre scientists have a key role to play in meeting the demand of EU citizens and industry, who want to see a big reduction in mandatory animal testing via new methodologies, Dr Julia Fentem told EURACTIV in an interview. EURACTIV SPECIAL REPORT ON ALTERNATIVES TO ANIMAL […]

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