• Systematic review: Performance of preclinical models in predicting drug-induced liver injury in humans

    A systematic review found that preclinical studies using animals fail to predict a drug’s potential to cause adverse health effects, despite being mandatory in safety and efficacy trials. HUMAN HEALTH ISSUES A collaboration of researchers conducted a comprehensive evaluation of the in vivo and in vitro tests currently available to assess drug safety and compared […]

    Continue reading
  • Non-animal Methods in Science and Regulation – EURL ECVAM status report (2020)

    This EURL ECVAM report provides information on the progress being made in the development, validation and regulatory application of non-animal methods, as well as on their use and promotion for research purposes, and in education and training programmes. INTRODUCTION EU policies and legislation call for innovative and more efficient ways of safety testing and chemical […]

    Continue reading
  • Opacimeter as a reliable method in tests for eye irritation

    Twelve years have gone by, but now it is a fact. The unique laser device which, without the use of live animals, can measure whether a certain product will have a harmful effect on a human eye is included in the OECD (Organisation for Economic Cooperation and Development) guideline for eye irritation. The device was […]

    Continue reading
  • Animal-free science innovations for better COVID-19 research

    A great deal of knowledge about the SARS-CoV-2 virus and the COVID-19 disease is needed quickly. In April this year, the Dutch Ministry of Health, Welfare and Sport (VWS) made 40 million euros available to ZonMw and NWO for COVID-19. Experimental animal-free innovations enable research to be carried out better and faster because the results […]

    Continue reading
  • Vaccine testing without animal testing?

    Dutch, Bilthoven based, Intravacc, a global leader in translational research and development of viral and bacterial vaccines, today announced the publication of a study in Scientific Reports on alternatives to the use of laboratory animals in vaccine quality control. The study was conducted together with Leiden Academic Center for Drug Research (LACDR) at Leiden University. […]

    Continue reading
  • The convalescent sera option for containing COVID-19

    With a vaccine for COVID-19 still a long way from being realized, Johns Hopkins University is working to revive a century-old blood-derived treatment in hopes of slowing the spread of the disease.   HUMAN HEALTH ISSUE Even at their most effective – and draconian – containment strategies have only slowed the spread of the respiratory […]

    Continue reading
  • Smoking robot and lung-on-a-chip to study cigarette smoke-induced lung diseases

    Researchers at the Wyss Institute at Harvard University have developed an animal-free science innovation platform by combining a robotic smoking machine with a lung-on-a-chip technology to fully and realistically mimic human smoking patterns. HUMAN HEALTH ISSUE Evaluating the health impact of airborne compounds is critical to determining pathogenesis and mechanisms of injury. Cigarette smoking is […]

    Continue reading
  • Scientists can bio-print a 3D mini liver in 90 days

    Using human blood cells, researchers have succeeded in obtaining hepatic organoids (“mini-livers”) that perform all of the liver’s typical functions, such as producing vital proteins, storing vitamins, and secreting bile, among many others. The innovation permits the production of hepatic tissue in the laboratory in only 90 days and may in the future become an […]

    Continue reading
  • Report on ‘Animal Experimentation: working towards a Paradigm Change’ Book Launch at the European Parliament

    On December 4, 2019 Animal Free Science, together with the Center for Alternatives to Animal Testing (CAAT) organized the launch of the book project entitled ‘Animal Experimentation: Working Towards a Paradigm Change‘ (Brill open access) at the European Parliament, to engage with scientists and politicians and stimulate the transition to better science and healthcare by […]

    Continue reading
  • We don’t want to make mice better but people

    The transition away from animal testing is for the time being a predominantly silent revolution, but alternatives based on human tissues and mini-organs offer the prospect of acceleration. “This is not only much more relevant for patients,” says Christine Mummery from the Leiden University Medical Center (LUMC), “But it is also faster and cheaper in […]

    Continue reading