• Green MEP Tilly Metz calls for EU action plan on alternatives to animal testing

    All initiatives to promote alternatives to animal testing are welcome, but lawmakers should be bolder and impose some mandatory measures as well, Luxembourgish MEP Tilly Metz has said. EURACTIV SPECIAL REPORT According to the Green MEP, policymakers must not give up their ambition of making  the “3 Rs” approach to animal testing mandatory. The “3 […]

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  • The potential of organoids and kidney-on-a-chip platforms as better predictive models for drug-induced nephrotoxicity

    A new review from scientists at the University of Utrecht considers how the complex nature of the kidney complicates in vitro modeling & suggests where 3D culture & organoid advances can be used to develop better predictive models that could reduce drug-induced nephrotoxicity. HUMAN HEALTH ISSUE The kidneys play an essential role in preserving homeostasis […]

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  • Mice brains are too different from humans’ to model neurodevelopmental disorders

    Most knowledge about how the development of the cerebellum – the brain area that receives and coordinates sensory information and our physical responses to it – comes from mice. A new study offers an explanation as to why brain studies in mice might fail to translate to humans. According to the scientists it is now […]

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  • Human liver-on-a-chip predicts human toxicity better than animal studies

    A new organ-on-a-chip system can predict human toxicity that was undetected in animal studies for drugs halted in clinical trials and emphasizes species-specific responses in liver toxicity. HUMAN HEALTH ISSUE Rats, dogs and other animals are used to test whether drugs are toxic to humans before the drugs are given to people. Candidate drug testing […]

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  • Time to move beyond the 3R principles

    This recently published study says the time has now come to prioritise the Replacement of animals used for scientific purposes, over refinement and reduction strategies. The 21st Century has already seen the development of a wide range of non-animal methods incorporating complex cell cultures, organs-on-a-chip and computer modelling. These methods are more relevant to human […]

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  • Book review: Rigor mortis

    Scientific research should not be attached to particular dogmas or paradigms but, on the contrary, change its methods according to the results obtained. In his book “Rigor Mortis”, the science journalist Richard Harris denounces the cost -financial and human- of a botched science, too often stuck in “animal models”. As an experienced science journalist, Richard […]

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  • A 3D Model of the Human Blood Brain Barrier

    Researchers at Vanderbilt University have developed a 3D tissue culture of the human brain endothelium that mimics in vivo properties of brain microvasculature and the blood brain barrier and can be used to study diseases and develop therapeutics.

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  • Pancreas-on-a-Chip Offers New Possibilities for Cystic Fibrosis Research

    Researchers at Cincinnati Children’s Hospital Medical Center have developed a human pancreas-on-a-chip to identify possible causes of cystic fibrosis-related diabetes (CFRD), a common and deadly comorbidity in people with cystic fibrosis (CF), and to further our understanding of pancreatic function.

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